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HRID2390293

反应详情

EQUATION

反应方程式

HRID 2390293 的结构方程式

REACTANTS

反应物

3
结构：CC1(C)C(=O)c2ccc(Br)cc2S1(=O)=O
HCID56594109

Benzo[b]thiophen-3(2H)-one, 6-bromo-2,2-dimethyl-, 1,1-dioxide

C10H9BrO3S

2 次

结构：C#Cc1cc(Cl)ccc1OCC(=O)OC(C)(C)C
HCID56594381

未命名化合物

2 次

结构：CCCS(=O)(=O)c1ccc(F)c(C#C[Si](C)(C)C)c1
HCID58521874

未命名化合物

PRODUCTS

生成物

1
结构：CC(C)(C)OC(=O)COc1ccc(Cl)cc1C#Cc1ccc2c(c1)S(=O)(=O)C(C)(C)C2=O
HCID58521949

未命名化合物

收率 91%

PROCEDURE

实验过程

Following the general method as outlined in Intermediate 107, starting from (4-chloro-2-ethynyl-phenoxy)-acetic acid tert-butyl ester (Intermediate 3) and 6-bromo-2,2-dimethyl-1-benzothiophen-3(2H)-one 1,1-dioxide (Intermediate 241), the title compound was obtained in 91% yield after purification by flash column chromatography (silica), eluting with cyclohexane containing increasing amounts of EtOAc.