反应详情

Following the general method as outlined in Intermediate 107, starting from (4-chloro-2-ethynyl-phenoxy)-acetic acid tert-butyl ester (Intermediate 3) and 6-bromo-2,2,3-trimethyl-2,3-dihydro-1-benzothiophene-3-ol 1,1-dioxide (Intermediate 246), the title compound was obtained as a white foam after purification by flash column chromatography (silica), eluting with cyclohexane containing increasing amounts of EtOAc.