1-Propanamine, N-ethyl- → HCID 58521844, compound

HRID 2390308Notes

Reaction equation

HRID 2390308 reaction equation
[Br:1][C:2]1[CH:15]=[CH:14][C:5]([C:6]([N:8]([CH2:10][CH2:11][CH2:12]C)[CH3:9])=[O:7])=[C:4]([S:16]([CH:19]([CH3:21])[CH3:20])(=[O:18])=[O:17])[CH:3]=1.Br[C:23]1C=CC(C(O)=O)=C(S(C(C)C)(=O)=O)C=1.C(NCCC)C>>[Br:1][C:2]1[CH:15]=[CH:14][C:5]([C:6]([N:8]([CH2:9][CH3:23])[CH2:10][CH2:11][CH3:12])=[O:7])=[C:4]([S:16]([CH:19]([CH3:21])[CH3:20])(=[O:18])=[O:17])[CH:3]=1

Participants

4

Reactant 3

HCID 883981-Propanamine, N-ethyl-HCID 56594115HCID 56594115, compound2×HCID 58521909HCID 58521909, compound

Product 1

HCID 58521844HCID 58521844, compoundYield 80%

Procedure

Following the general method as outlined in Intermediate 253, starting from 4-bromo-2-(isopropylsulfonyl)benzoic acid (Intermediate 242) and N-ethyl-N-propylamine, the title compound was obtained as a pink solid in 80% yield.

Sources & evidence

ORD record
ord-6b591dbe425d47d7b61d4bab2cb7f9f1
Source dataset
uspto-grants-2012_09
Patent number
US08273769B2

Reaction notes

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