Hydrochloric Acid → 4-Chloro-2-{[2-methyl-5-(propylsulfonyl)phenyl]ethynyl}phenol

Participants

Reaction Steps

3-{[5-Chloro-2-(methoxymethoxy)phenyl]ethynyl}-4-methylphenyl propyl sulfone (Intermediate 266; 1.09 g; 2.77 mmol) was treated with a 4 N solution hydrogen chloride in 1,4-dioxane (21 ml) and stirred at RT for 7 hours. The reaction mixture was concentrated to dryness under reduced pressure to afford the title compound as a beige solid (884 mg; 91%).

Provenance & Evidence