HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 2-bromo-4-methylpentanoate → Ethyl 2-(4-chloro-2-{[2-methyl-5-(propylsulfonyl)phenyl]ethynyl}phenoxy)-4-methylpentanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 2-bromo-4-methylpentanoate | HCID 458111 | — |
| Reactant | 4-Chloro-2-{[2-methyl-5-(propylsulfonyl)phenyl]ethynyl}phenol | HCID 56593973 | — |
| Product | Ethyl 2-(4-chloro-2-{[2-methyl-5-(propylsulfonyl)phenyl]ethynyl}phenoxy)-4-methylpentanoate | HCID 58521941 | 81% |
Reaction Steps
Following the general method as outlined in Intermediate 268, starting from 4-chloro-2-{[2-methyl-5-(propylsulfonyl)phenyl]ethynyl}phenol (Intermediate 267) and 2-bromo-4-methyl-pentanoic acid ethyl ester, the title compound was obtained as a colorless sticky solid in 81% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08273769B2 |
| Source dataset | uspto-grants-2012_09 |
| ORD ID | ord-a001dfa300844a8f88fae55f5627af07 |
| Source note | uspto-grants-2012_09 |