2-Bromo-1-methyl-1H-imidazole → HCID 46865759, compound

HRID 2390327Notes

Reaction equation

HRID 2390327 reaction equation
C([O:5][C:6](=[O:18])[CH2:7][O:8][C:9]1[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][C:10]=1[C:16]#[CH:17])(C)(C)C.Br[C:20]1[N:21]([CH3:25])[CH:22]=[CH:23][N:24]=1>>[Cl:15][C:12]1[CH:13]=[CH:14][C:9]([O:8][CH2:7][C:6]([OH:5])=[O:18])=[C:10]([C:16]#[C:17][C:20]2[N:21]([CH3:25])[CH:22]=[CH:23][N:24]=2)[CH:11]=1

Participants

3

Reactant 2

HCID 27732622-Bromo-1-methyl-1H-imidazoleHCID 56594381Tert-butyl(4-chloro-2-ethynylphenoxy)acetate2×

Product 1

HCID 46865759HCID 46865759, compound

Procedure

Following the general method as outlined in Example 10, starting from tert-butyl(4-chloro-2-ethynylphenoxy)acetate (Intermediate 3) and 2-bromo-1-methyl-1H-imidazole (Aldrich), the title compound was obtained as an off-white solid after purification by preparative HPLC.

Sources & evidence

ORD record
ord-8b08cca14f1c45428c3754b32e37c471
Source dataset
uspto-grants-2012_09
Patent number
US08273769B2

Reaction notes

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