4-Bromopyridinium chloride → HCID 56594385, compound

HRID 2390328Notes

Reaction equation

HRID 2390328 reaction equation
C([O:5][C:6](=[O:18])[CH2:7][O:8][C:9]1[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][C:10]=1[C:16]#[CH:17])(C)(C)C.Cl.Br[C:21]1[CH:26]=[CH:25][N:24]=[CH:23][CH:22]=1>>[Cl:15][C:12]1[CH:13]=[CH:14][C:9]([O:8][CH2:7][C:6]([OH:5])=[O:18])=[C:10]([C:16]#[C:17][C:21]2[CH:26]=[CH:25][N:24]=[CH:23][CH:22]=2)[CH:11]=1

Participants

3

Reactant 2

HCID 881004-Bromopyridinium chlorideHCID 56594381Tert-butyl(4-chloro-2-ethynylphenoxy)acetate2×

Product 1

HCID 56594385HCID 56594385, compound

Procedure

Following the general method as outlined in Example 10, starting from tert-butyl(4-chloro-2-ethynylphenoxy)acetate (Intermediate 3) and 4-bromopyridine hydrochloride (Fluka), the title compound was obtained as a yellow solid after purification by precipitation in dioxane.

Sources & evidence

ORD record
ord-0aa5739a6e9c40efb44d10a2da27879d
Source dataset
uspto-grants-2012_09
Patent number
US08273769B2

Reaction notes

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