Hydrochloric Acid → {4-Chloro-2-[(4-methylpyridin-3-yl)ethynyl]phenoxy}acetic acid

Participants

Reaction Steps

A solution of tert-butyl{4-chloro-2-[(4-methylpyridin-3-yl)ethynyl]phenoxy}acetate (Intermediate 19, 138 mg; 0.39 mmol) in DCM (1.4 mL) was treated with an HCl solution (4 N in dioxane, 2.7 mL). After stirring for 20 hours, the solvents were removed under vacuum to afford the title compound as a beige solid (107 mg, 82%).

Provenance & Evidence