Tert-butyl(4-chloro-2-ethynylphenoxy)acetate → HCID 56594517, compound

HRID 2390334Notes

Reaction equation

HRID 2390334 reaction equation
C([O:5][C:6](=[O:18])[CH2:7][O:8][C:9]1[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][C:10]=1[C:16]#[CH:17])(C)(C)C.Br[C:20]1[CH:21]=[C:22]([S:26]([CH2:29][CH2:30][OH:31])(=[O:28])=[O:27])[CH:23]=[CH:24][CH:25]=1>>[Cl:15][C:12]1[CH:13]=[CH:14][C:9]([O:8][CH2:7][C:6]([OH:5])=[O:18])=[C:10]([C:16]#[C:17][C:20]2[CH:25]=[CH:24][CH:23]=[C:22]([S:26]([CH2:29][CH2:30][OH:31])(=[O:28])=[O:27])[CH:21]=2)[CH:11]=1

Participants

3

Reactant 2

HCID 56594381Tert-butyl(4-chloro-2-ethynylphenoxy)acetate2×HCID 58522057HCID 58522057, compound2×

Product 1

HCID 56594517HCID 56594517, compound

Procedure

Following the general method as outlined in Example 10, starting from tert-butyl(4-chloro-2-ethynylphenoxy)acetate (Intermediate 3) and 2-(3-bromo-benzenesulfonyl)-ethanol (Intermediate 7), the title compound was obtained as a beige solid after purification by preparative HPLC.

Sources & evidence

ORD record
ord-ea3415239dea425d932b6d559263ec81
Source dataset
uspto-grants-2012_09
Patent number
US08273769B2

Reaction notes

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