2-Ethynyl-1-methyl-4-(propylsulfonyl) benzene → (4-Cyano-2-{[5-(ethylsulfonyl)-2-methylphenyl]ethynyl}phenoxy)acetic acid

HRID 2390348Notes

Reaction equation

HRID 2390348 reaction equation
C([O:5][C:6](=[O:19])[CH2:7][O:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]#[N:16])=[CH:11][C:10]=1[C:17]#[CH:18])(C)(C)C.C([C:22]1[CH:27]=[C:26]([S:28]([CH2:31][CH2:32]C)(=[O:30])=[O:29])[CH:25]=[CH:24][C:23]=1[CH3:34])#C>>[C:15]([C:12]1[CH:13]=[CH:14][C:9]([O:8][CH2:7][C:6]([OH:5])=[O:19])=[C:10]([C:17]#[C:18][C:24]2[CH:25]=[C:26]([S:28]([CH2:31][CH3:32])(=[O:29])=[O:30])[CH:27]=[CH:22][C:23]=2[CH3:34])[CH:11]=1)#[N:16]

Participants

3

Reactant 2

HCID 585220332-Ethynyl-1-methyl-4-(propylsulfonyl) benzene2×HCID 58522073Tert-butyl(4-cyano-2-ethynylphenoxy)acetate2×

Product 1

HCID 46866075(4-Cyano-2-{[5-(ethylsulfonyl)-2-methylphenyl]ethynyl}phenoxy)acetic acid

Procedure

Following the general method as outlined in Example 37, starting from tert-butyl(4-cyano-2-ethynyl phenoxy)acetate (Intermediate 46) and 2-ethynyl-1-methyl-4-(propylsulfonyl)benzene (Intermediate 40), the title compound was obtained as a yellow solid.

Sources & evidence

ORD record
ord-cef2e0bfc2784c4daecd8255c48f2dd0
Source dataset
uspto-grants-2012_09
Patent number
US08273769B2

Reaction notes

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