5-Bromo-N,N-dimethylpyridine-3-sulfonamide → HCID 58521855, compound

HRID 2390351Notes

Reaction equation

HRID 2390351 reaction equation
C([O:5][C:6](=[O:19])[CH2:7][O:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]#[N:16])=[CH:11][C:10]=1[C:17]#[CH:18])(C)(C)C.[CH3:20][N:21]([CH3:32])[S:22]([C:25]1[CH:26]=[N:27][CH:28]=[C:29](Br)[CH:30]=1)(=[O:24])=[O:23]>>[C:15]([C:12]1[CH:13]=[CH:14][C:9]([O:8][CH2:7][C:6]([OH:5])=[O:19])=[C:10]([C:17]#[C:18][C:29]2[CH:28]=[N:27][CH:26]=[C:25]([S:22]([N:21]([CH3:32])[CH3:20])(=[O:23])=[O:24])[CH:30]=2)[CH:11]=1)#[N:16]

Participants

3

Reactant 2

HCID 467389545-Bromo-N,N-dimethylpyridine-3-sulfonamide2×HCID 58522073Tert-butyl(4-cyano-2-ethynylphenoxy)acetate2×

Product 1

HCID 58521855HCID 58521855, compound

Procedure

Following the general method as outlined in Example 37, starting from tert-butyl(4-cyano-2-ethynyl phenoxy)acetate (Intermediate 46) and 5-bromo-pyridine-3-sulfonic acid dimethylamide (Intermediate 32), the title compound was obtained as a yellow solid.

Sources & evidence

ORD record
ord-51c81f82537f44deb0e7f605c260a6d1
Source dataset
uspto-grants-2012_09
Patent number
US08273769B2

Reaction notes

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