HCID 58522069, compound → HCID 46866174, compound

HRID 2390357Notes

Reaction equation

HRID 2390357 reaction equation
C([O:5][C:6](=[O:19])[CH2:7][O:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]#[N:16])=[CH:11][C:10]=1[C:17]#[CH:18])(C)(C)C.Br[C:21]1[CH:22]=[N:23][CH:24]=[C:25]([S:27]([N:30]2[CH2:33][C:32]([F:35])([F:34])[CH2:31]2)(=[O:29])=[O:28])[CH:26]=1>>[C:15]([C:12]1[CH:13]=[CH:14][C:9]([O:8][CH2:7][C:6]([OH:5])=[O:19])=[C:10]([C:17]#[C:18][C:21]2[CH:22]=[N:23][CH:24]=[C:25]([S:27]([N:30]3[CH2:33][C:32]([F:35])([F:34])[CH2:31]3)(=[O:29])=[O:28])[CH:26]=2)[CH:11]=1)#[N:16]

Participants

3

Reactant 2

HCID 58522069HCID 58522069, compound2×HCID 58522073Tert-butyl(4-cyano-2-ethynylphenoxy)acetate2×

Product 1

HCID 46866174HCID 46866174, compound

Procedure

Following the general method as outlined in Example 35, starting from tert-butyl(4-cyano-2-ethynyl phenoxy)acetate (Intermediate 46) and 3-bromo-5-[(3,3-difluoroazetidin-1-yl)sulfonyl]pyridine (Intermediate 34), the title compound was obtained as an off-white solid.

Sources & evidence

ORD record
ord-9578749183dc4c5eb35c27c2fa41f09e
Source dataset
uspto-grants-2012_09
Patent number
US08273769B2

Reaction notes

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