4-(5-Bromopyridine-3-sulfonyl)morpholine → HCID 46866173, compound

HRID 2390358Notes

Reaction equation

HRID 2390358 reaction equation
C([O:5][C:6](=[O:19])[CH2:7][O:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]#[N:16])=[CH:11][C:10]=1[C:17]#[CH:18])(C)(C)C.Br[C:21]1[CH:22]=[C:23]([S:27]([N:30]2[CH2:35][CH2:34][O:33][CH2:32][CH2:31]2)(=[O:29])=[O:28])[CH:24]=[N:25][CH:26]=1>>[C:15]([C:12]1[CH:13]=[CH:14][C:9]([O:8][CH2:7][C:6]([OH:5])=[O:19])=[C:10]([C:17]#[C:18][C:21]2[CH:26]=[N:25][CH:24]=[C:23]([S:27]([N:30]3[CH2:31][CH2:32][O:33][CH2:34][CH2:35]3)(=[O:29])=[O:28])[CH:22]=2)[CH:11]=1)#[N:16]

Participants

3

Reactant 2

HCID 253071984-(5-Bromopyridine-3-sulfonyl)morpholineHCID 58522073Tert-butyl(4-cyano-2-ethynylphenoxy)acetate2×

Product 1

HCID 46866173HCID 46866173, compound

Procedure

Following the general method as outlined in Example 35, starting from tert-butyl(4-cyano-2-ethynyl phenoxy)acetate (Intermediate 46) and 4-[(5-bromopyridin-3-yl)sulfonyl]morpholine (Apollo), the title compound was obtained as an off-white solid.

Sources & evidence

ORD record
ord-0a958c5a45a34f818dc49026d762da41
Source dataset
uspto-grants-2012_09
Patent number
US08273769B2

Reaction notes

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