Tert-butyl(4-chloro-2-ethynylphenoxy)acetate → HCID 58521919, compound

HRID 2390359Notes

Reaction equation

HRID 2390359 reaction equation
C([O:5][C:6](=[O:18])[CH2:7][O:8][C:9]1[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][C:10]=1[C:16]#[CH:17])(C)(C)C.Br[C:20]1[CH:21]=[N:22][CH:23]=[C:24]([S:26]([N:29]2[CH2:32][C:31]([F:34])([F:33])[CH2:30]2)(=[O:28])=[O:27])[CH:25]=1>>[Cl:15][C:12]1[CH:13]=[CH:14][C:9]([O:8][CH2:7][C:6]([OH:5])=[O:18])=[C:10]([C:16]#[C:17][C:20]2[CH:21]=[N:22][CH:23]=[C:24]([S:26]([N:29]3[CH2:32][C:31]([F:34])([F:33])[CH2:30]3)(=[O:28])=[O:27])[CH:25]=2)[CH:11]=1

Participants

3

Reactant 2

HCID 56594381Tert-butyl(4-chloro-2-ethynylphenoxy)acetate2×HCID 58522069HCID 58522069, compound2×

Product 1

HCID 58521919HCID 58521919, compound

Procedure

Following the general method as outlined in Example 35, starting from tert-butyl(4-chloro-2-ethynyl phenoxy)acetate (Intermediate 3) and 3-bromo-5-[(3,3-difluoroazetidin-1-yl)sulfonyl]pyridine (Intermediate 34), the title compound was obtained as an off-white solid.

Sources & evidence

ORD record
ord-b14fcdc1b0de4249b208ba0721ff1a87
Source dataset
uspto-grants-2012_09
Patent number
US08273769B2

Reaction notes

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