4-(5-Bromopyridine-3-sulfonyl)morpholine → HCID 56595050, compound

HRID 2390360Notes

Reaction equation

HRID 2390360 reaction equation
C([O:5][C:6](=[O:18])[CH2:7][O:8][C:9]1[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][C:10]=1[C:16]#[CH:17])(C)(C)C.Br[C:20]1[CH:21]=[C:22]([S:26]([N:29]2[CH2:34][CH2:33][O:32][CH2:31][CH2:30]2)(=[O:28])=[O:27])[CH:23]=[N:24][CH:25]=1>>[Cl:15][C:12]1[CH:13]=[CH:14][C:9]([O:8][CH2:7][C:6]([OH:5])=[O:18])=[C:10]([C:16]#[C:17][C:20]2[CH:25]=[N:24][CH:23]=[C:22]([S:26]([N:29]3[CH2:30][CH2:31][O:32][CH2:33][CH2:34]3)(=[O:28])=[O:27])[CH:21]=2)[CH:11]=1

Participants

3

Reactant 2

HCID 253071984-(5-Bromopyridine-3-sulfonyl)morpholineHCID 56594381Tert-butyl(4-chloro-2-ethynylphenoxy)acetate2×

Product 1

HCID 56595050HCID 56595050, compound

Procedure

Following the general method as outlined in Example 35, starting from tert-butyl(4-chloro-2-ethynyl phenoxy)acetate (Intermediate 3) and 4-[(5-bromopyridin-3-yl)sulfonyl]morpholine (Apollo), the title compound was obtained as an off-white solid.

Sources & evidence

ORD record
ord-e682298637a44be6ad66a36f4303340e
Source dataset
uspto-grants-2012_09
Patent number
US08273769B2

Reaction notes

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