HCID 58521921, compound → HCID 58521832, compound

HRID 2390364Notes

Reaction equation

HRID 2390364 reaction equation
C([O:5][C:6](=[O:19])[CH2:7][O:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]#[N:16])=[CH:11][C:10]=1[C:17]#[CH:18])(C)(C)C.Br[C:21]1[CH:26]=[C:25]([S:27]([CH2:30][CH2:31][C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=2)(=[O:29])=[O:28])[CH:24]=[CH:23][C:22]=1[CH3:38]>>[C:15]([C:12]1[CH:13]=[CH:14][C:9]([O:8][CH2:7][C:6]([OH:5])=[O:19])=[C:10]([C:17]#[C:18][C:23]2[CH:24]=[C:25]([S:27]([CH2:30][CH2:31][C:32]3[CH:33]=[CH:34][CH:35]=[CH:36][CH:37]=3)(=[O:29])=[O:28])[CH:26]=[CH:21][C:22]=2[CH3:38])[CH:11]=1)#[N:16]

Participants

3

Reactant 2

HCID 58521921HCID 58521921, compound2×HCID 58522073Tert-butyl(4-cyano-2-ethynylphenoxy)acetate2×

Product 1

HCID 58521832HCID 58521832, compound

Procedure

Following the general method as outlined in Example 37, starting from tert-butyl(4-cyano-2-ethynyl phenoxy)acetate (Intermediate 46) and 2-bromo-1-methyl-4-[(2-phenylethyl)sulfonyl]benzene (Intermediate 70), the title compound was obtained as a yellow solid.

Sources & evidence

ORD record
ord-84dee382729f469ea49a16c71a16d954
Source dataset
uspto-grants-2012_09
Patent number
US08273769B2

Reaction notes

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