2-(2-Bromo-4-chlorophenoxy)-2-methylpropanoate → 2-(4-Chloro-2-{[2-fluoro-5-(propylsulfonyl)phenyl]ethynyl}phenoxy)-2-methylpropanoic acid

Participants

Role	Name	HCID	Charge
Reactant	2-(2-Bromo-4-chlorophenoxy)-2-methylpropanoate	HCID 42233305	—
Reactant	2-Ethynyl-1-fluoro-4-(propylsulfonyl)benzene	HCID 58521935	—
Product	2-(4-Chloro-2-{[2-fluoro-5-(propylsulfonyl)phenyl]ethynyl}phenoxy)-2-methylpropanoic acid	HCID 56595570	—

Reaction Steps

Following the general method as outlined in Example 168, starting from 2-(2-bromo-4-chlorophenoxy)-2-methylpropanoate (Intermediate 264), and 2-ethynyl-1-fluoro-4-(propane-1-sulfonyl)-benzene (Intermediate 109) the title compound was obtained as a brown sticky solid after purification by preparative HPLC.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08273769B2
Source dataset	uspto-grants-2012_09
ORD ID	ord-519629195efe4a02877a406ce99eb653
Source note	uspto-grants-2012_09