Hydrochloric Acid → HCID 56595571, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 4-chloro-2-{[2-methyl-5-(propylsulfonyl)phenyl]ethynyl}phenol (150 mg; 0.43 mmol) and methyl-2-bromopropionate (53 μl; 0.47 mmol) in DME (3 ml) was treated with K2CO3 (89 mg, 69 mmol) and heated at 70° C. for 4.5 hours. The reaction mixture was filtered and the filtrate was concentrated affording a sticky solid, which was dissolved in MeOH (1.5 ml) and treated with a 1 N solution of NaOH in water (129 μl) and the mixture heated for 1 hour at 70° C. A 5 N solution of HCl in water (52 μl) was added and the solvents removed under reduced pressure, to give a residue which was purified by preparative HPLC to give the title compound as a white solid.

Provenance & Evidence