HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylamine → 4-(7-Bromo-3-isoquinolinyl)benzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylamine | HCID 7912 | — |
| Reactant | 4-Ethynylbenzonitrile | HCID 4547245 | — |
| Reactant | HCID 178448919 | HCID 178448919 | — |
| Catalyst | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| Catalyst | HCID 178418476 | HCID 178418476 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 4-(7-Bromo-3-isoquinolinyl)benzonitrile | HCID 67104258 | — |
Reaction Steps
The product from Example 62D (3.6 mmol), 4-cyanophenylacetylene (4.3 mmol), CuI (0.2 mmol), PdCl2(PPh3)2 (0.1 mmol), and diisopropylamine (5.3 mmol) can be combined in toluene (15 mL) and processed as described in Example 62E to provide the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08273767B2 |
| Source dataset | uspto-grants-2012_09 |
| ORD ID | ord-1178ac53b86445799ddf47cda10da5c3 |
| Source note | uspto-grants-2012_09 |