1,1'-Thiocarbonyldi-2(1H)-pyridone → HCID 59857388, compound

HRID 2390500Notes

Reaction equation

HRID 2390500 reaction equation
[C:1]([C:5]1[CH:18]=[CH:17][CH:16]=[CH:15][C:6]=1[O:7][C:8]1[C:13]([NH2:14])=[CH:12][CH:11]=[CH:10][N:9]=1)([CH3:4])([CH3:3])[CH3:2].[C:19](N1C=CC=CC1=O)(N1C=CC=CC1=O)=[S:20]>C(Cl)Cl>[C:1]([C:5]1[CH:18]=[CH:17][CH:16]=[CH:15][C:6]=1[O:7][C:8]1[C:13]([N:14]=[C:19]=[S:20])=[CH:12][CH:11]=[CH:10][N:9]=1)([CH3:4])([CH3:2])[CH3:3]

Participants

4

Reactant 2

HCID 8531621,1'-Thiocarbonyldi-2(1H)-pyridoneHCID 286054272-(2-Tert-butylphenoxy)pyridin-3-amine

Product 1

HCID 59857388HCID 59857388, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A mixture of 2-(2-tert-Butylphenoxy)-3-aminopyridine (Example 203b) (5.21 g, 21.5 mmol) and 1,1′-thiocarbonyldi-2(1H)-pyridone (5 g, 21.5 mmol) in DCM (100 mL) was stirred at rt for 18 h. The mixture was evaporated and the solid was dissolved in hexanes/DCM (50 mL, 9/1). The residual solid was removed by filtration and the solution was evaporated to provide the title compound as a brown solid. (M+H)+=285.

Workup

  1. customThe mixture was evaporated
  2. dissolutionthe solid was dissolved in hexanes/DCM (50 mL, 9/1)
  3. customThe residual solid was removed by filtration
  4. customthe solution was evaporated

Sources & evidence

ORD record
ord-9b46ac4b31f241ada25b124848b07374
Source dataset
uspto-grants-2012_09
Patent number
US08273772B2

Reaction notes

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