Bromine → 395-15-3

HRID 2390518Notes

Reaction equation

HRID 2390518 reaction equation
[F:1][C:2]([F:13])([F:12])[C:3](=[O:11])[CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1.[Br:14]Br>C(OCC)C>[Br:14][CH:4]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)[C:3](=[O:11])[C:2]([F:12])([F:13])[F:1]

Participants

4

Reactant 2

HCID 24408BromineHCID 2229581,1,1-Trifluoro-3-phenyl-2-propanone

Product 1

HCID 14026649395-15-3

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Conditions

Temperature
0 °C

Procedure

1,1,1-trifluoro-3-phenylpropanone (0.50 mL, 3.2 mmol) was dissolved in 5 mL of diethyl ether and the mixture was cooled to 0° C. Bromine (0.16 mL, 3.2 mmoL) was added and the mixture was stirred for 18 h and allowed to warm to rt. The solvent was removed to provide a 2:1 mixture of Example A176a as a starting material which was used in the subsequent reaction without further purification.

Workup

  1. temperatureto warm to rt
  2. customThe solvent was removed
  3. customto provide
  4. customwas used in the subsequent reaction without further purification

Sources & evidence

ORD record
ord-160e9f46aa354ddf97c9f272b54388c1
Source dataset
uspto-grants-2012_09
Patent number
US08273772B2

Reaction notes

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