5-Bromosalicylaldehyde → HCID 67025664, compound

Participants

Reaction Steps

To a solution of 5-bromo-2-hydroxybenzaldehyde (1 g, 4.97 mmol) in DCM (50 mL) was added (2R,6S)-2,6-dimethylpiperazine (0.852 g, 7.46 mmol). The mixture was allowed to stir at RT for 40 min before sodium triacetoxyborohydride (1.582 g, 7.46 mmol) was added. The reaction was stirred at RT for 24 h. The mixture was diluted with DCM and washed with sat. NaHCO3 (aq), dried (MgSO4) and evaporated to give a white foam. This was purified by Biotage (eluent=2.5% 7M ammonia in methanol/DCM) to give the sub-title compound as a white solid. Yield: 1.32 g

Provenance & Evidence