Pyrazolo(1,5-a)pyridine-2-carboxylic acid → 4,5,6,7-Tetrahydropyrazolo[1,5-a]pyridine-2-carboxylic acid

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Reaction Steps

A solution of pyrazolo[1,5-a]pyridine-2-carboxylic acid (1 g, 6.17 mmol) in methanol (100 mL) was hydrogenated at 3½ bar over 5% rhodium on carbon (100 mg) overnight. The mixture was filtered through Celite and the pad was washed with methanol. The filtrates were evaporated to give the sub-title compound as a cream powder. Yield: 0.953 g

Provenance & Evidence