Sodium Hydroxide → HCID 43664321, compound

HRID 2390554Notes

Reaction equation

HRID 2390554 reaction equation
[OH-].[Na+].C([O:6][CH2:7][C:8]1[N:9]=[C:10]([C:13]([O:15]CC)=[O:14])[S:11][CH:12]=1)(=O)C>CO>[OH:6][CH2:7][C:8]1[N:9]=[C:10]([C:13]([OH:15])=[O:14])[S:11][CH:12]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 67025539HCID 67025539, compound

Product 1

HCID 43664321HCID 43664321, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

2M NaOH (4.58 mL, 9.16 mmol) was added to a solution of ethyl 4-(acetoxymethyl)thiazole-2-carboxylate (0.7 g, 3.05 mmol) in MeOH (3 mL) and stirred for 1 h. Acidified with 2M HCl, purified by reverse phase HPLC with aqTFA/MeOH as eluent and freeze dried to afford the sub-title compound as a white solid. Yield: 0.510 g

Workup

  1. customAcidified with 2M HCl, purified by reverse phase HPLC with aqTFA/MeOH as eluent
  2. customfreeze dried

Sources & evidence

ORD record
ord-624a3db66e0c46059bc7a1abacd65615
Source dataset
uspto-grants-2012_09
Patent number
US08273774B2

Reaction notes

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