Sodium triacetoxyborohydride → HCID 67025669, compound

Participants

Reaction Steps

(2S,6R)-2,6-Dimethylpiperazine (0.304 g, 2.67 mmol) and (S)-4-bromo-3-((3-methylmorpholino)methyl)benzaldehyde (0.530 g, 1.78 mmol) in DCM (10 ml) were stirred at RT under nitrogen for 30 minutes. Sodium triacetoxyborohydride (0.565 g, 2.67 mmol) was then added and the resulting solution was stirred at RT over the weekend. The reaction mixture was quenched with saturated NaHCO3. The reaction mixture was extracted with DCM (×3). The organic layer was dried over MgSO4, filtered and evaporated to afford the sub-title compound as a yellow oil. Yield: 0.620 g

Provenance & Evidence