Sodium borohydride → HCID 67128148, compound

HRID 2390589Notes

Reaction equation

HRID 2390589 reaction equation
[F:1][C:2]1[CH:9]=[CH:8][C:7]([CH2:10][O:11][CH:12]2[CH2:17][CH2:16][CH2:15][CH2:14][O:13]2)=[CH:6][C:3]=1[CH:4]=[O:5].[BH4-].[Na+]>CO>[F:1][C:2]1[CH:9]=[CH:8][C:7]([CH2:10][O:11][CH:12]2[CH2:17][CH2:16][CH2:15][CH2:14][O:13]2)=[CH:6][C:3]=1[CH2:4][OH:5]

Participants

4

Reactant 2

HCID 4311764Sodium borohydrideHCID 86646365HCID 86646365, compound

Product 1

HCID 67128148HCID 67128148, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 2.5g (10.49 mmol) 2-fluoro-5-(tetrahydropyrane-2-yloxymethyl)-benzaldehyde in anhydrous methanol is mixed in portions with 0.60 g (15.7 mmol) sodium borohydride while stirring and stirred for another hour at room temperature. After adding water, extraction is performed using diethyl ether, and the organic phase is dried over sodium sulfate. After removing the solvent under vacuum, the benzyl alcohol is obtained in pure form.

Workup

  1. stirringstirred for another hour at room temperature
  2. additionAfter adding
  3. extractionwater, extraction
  4. dry with materialthe organic phase is dried over sodium sulfate
  5. customAfter removing the solvent under vacuum

Sources & evidence

ORD record
ord-15fb6455c09b4dc99b2d741003aacf09
Source dataset
uspto-grants-2012_09
Patent number
US08273793B2

Reaction notes

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