HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonium Hydroxide → (4-Amino-3-bromothieno[3,2-c]pyridin-7-yl)methanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonium Hydroxide | HCID 14923 | — |
| Reactant | (3-Bromo-4-chlorothieno[3,2-c]pyridin-7-yl)methyl acetate | HCID 18450772 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | (4-Amino-3-bromothieno[3,2-c]pyridin-7-yl)methanol | HCID 18450834 | 84% |
Reaction Steps
A mixture of Example 277D (3.1 g, 9.7 mmol), concentrated NH4OH (62 mL), and dioxane (62 mL) was heated to 150° C. in a sealed tube for 36 hours, filtered, and concentrated to provide a soid which was triturated with water (20 mL), collected and dried to give 2.1 g (84% yield) of the desired product. MS (ESI(+)) m/e 258.9, 260.8 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08273736B2 |
| Source dataset | uspto-grants-2012_09 |
| ORD ID | ord-23ae4384d50f4be8b8f4a72b7b6c8c06 |
| Source note | uspto-grants-2012_09 |