Reaction Steps
A solution of 212f (5.81 g, 8.33 mmol) in freshly distilled THF (50 mL) was added dropwise to a suspension of LiAlH4 (1.0 g, 26.4 mmol) in THF (50 mL) at −78° C. under a nitrogen atmosphere. The solution was warmed to room temperature over 4 h, then cooled back to −78° C., and quenched with ethyl acetate (5.0 mL). After warming to room temperature, water (100 mL) was added and the product was extracted with Et2O (2×100 mL). The ether extracts were combined, dried with sodium sulfate, filtered, and concentrated. After drying under high vacuum for 4 h, 213f (4.80 g, 94%) was obtained as a colorless oil. 1H NMR (CDCl3): δ 7.20 (d, 4 H, J=8.0), 7.09 (d, 4 H, J=8.0), 3.64 (d, 2 H, J=10.7), 3.48 (d, 2 H, J=10.7), 2.71 (t, 4 H, J=5.1), 2.50-2.35 (m br., 2 H), 2.43 (d, 4 H, J=7.0), 1.90-1.80 (m, 4 H), 1.80-1.68 (m, 6 H), 1.58-1.42 (m, 2 H), 1.38-1.25 (m, 4 H), 1.30 (s, 6 H), 1.26-1.10 (m, 2H), 1.10-0.95 (m, 2 H), 0.89 (d, 12 H, J=6.6). 13C NMR (CDCl3): δ 141.94, 139.39, 129.20, 126.44, 72.48, 53.30, 44.97, 43.09, 38.45, 38.18, 30.21, 26.01, 25.64, 24.84, 24.09, 22.55, 21.64. HRMS (LSIMS, nba): Calcd for C38H61O2S2 (MH+): 613.4113, found: 613.4075. HPLC: 97.6% pure.
