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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2390727Generated: October 29, 2026

1-Methyl-1H-indole-2-carbonyl chloride → N-(4-{4-amino-7-[(3-morpholin-4-ylpropanoyl)amino]thieno[3,2-c]pyridin-3-yl}-2-methoxyphenyl)-1-methyl-1H-indole-2-carboxamide

https://huagongshe.com/reaction/2390727

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-Methyl-1H-indole-2-carbonyl chlorideHCID 12303314—
ReactantN-[4-amino-3-(4-amino-3-methoxyphenyl)thieno[3,2-c]pyridin-7-yl]-3-morpholin-4-ylpropanamideHCID 18451409—
ProductN-(4-{4-amino-7-[(3-morpholin-4-ylpropanoyl)amino]thieno[3,2-c]pyridin-3-yl}-2-methoxyphenyl)-1-methyl-1H-indole-2-carboxamideHCID 18451209—

Reaction Steps

The title compound was prepared using 1-methyl-1H-indole-2-carbonyl chloride, N-[4-amino-3-(4-amino-3-methoxyphenyl)thieno[3,2-c]pyridin-7-yl]-3-morpholin-4-ylpropanamide, and the procedure described in General Procedure F. m/z (M+H)+ 585.4.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08273736B2
Source datasetuspto-grants-2012_09
ORD IDord-b07224a52db048149d5ebdf890c41e55
Source noteuspto-grants-2012_09