Potassium Carbonate → 1,4,7-Tris(tert-butoxycarbonylmethyl)-10-((4-tert-butyl)-benzylaminocarbonylmethyl)-1,4,7,10-tetraazacyclodo-decane

Participants

Reaction Conditions

Reaction Steps

A reaction mixture of 1,4,7-tris(tert-butoxycarbonylmethyl)-1,4,7,10-tetraaza-cyclododecane (7.57 g, 12.7 mmol), 2-chloro-N-(4-tert-butylphenylmethyl)-acetamide (3.60 g, 15 mmol) obtained from Example 2a and potassium carbonate (5.53 g, 40 mmol) in acetonitrile (100 ml) was heated to 75° C. and stirred under nitrogen-atmosphere overnight. The reaction mixture was cooled to room temperature and filtered. The filtrate was evaporated in vacuo and the residue was submitted to flash-chromatography (silica, MeOH/CHCl3). The fractions containing the product were combined and evaporated in vacuo resulting in the title compound being a yellow oil that crystallised upon storage.

Provenance & Evidence