Potassium Carbonate → HCID 50899431, compound

Participants

Reaction Steps

In a two-necked round-bottom flask, 4-[2-chloro-6-(2(S)-hydroxypropylamino)-pyrimidin-4-yl]-3-(3-methoxy-5-methylphenyl)-1H-pyrazol (900 mg, 2.4 mmol) was dissolved in acetone (30 mL) to which finely ground potassium carbonate (1.66 g, 12 mmol) was then added and refluxed for 2 hours. Iodoacetonitrile (0.2 mL, 3.36 mmol) was dropwise added, followed by reflux for an additional 2 hours. After completion of the reaction, the solvent was removed by vacuum distillation. The reaction mixture was dissolved in water and extracted with ethyl acetate. The organic layer was washed with brine and dried over anhydrous magnesium sulfate. The solvent was removed by vacuum distillation and the residue was purified through column chromatography to produce the title compound (430 mg, 43.4%).

Provenance & Evidence