Trifluoroborane-methyl sulfide → HCID 44517769, compound

Participants

Reaction Steps

To anhydrous dichloromethane (5 mL) was added [4-[6-(2(S)-hydroxypropylamino)-2-pyridin-3-yl-pyrimidin-4-yl]-3-(3-methoxy-5-ethylphenyl)pyrazol-1-yl]acetonitrile (150 mg, 0.33 mmol) and boron trifluoride-dimethylsulfide (344 μL, 3.27 mmol) under nitrogen atmosphere. The reaction mixture was stirred for 12 hours at room temperature under nitrogen atmosphere. After completion of the demethylation, the solvent was removed by vacuum distillation, and the reaction mixture was dissolved, extracted with ethyl acetate, washed with brine, dried over anhydrous magnesium sulfate, and concentrated through vacuum distillation. Column chromatography gave the title compound (64.89 mg, 45%).

Provenance & Evidence