反应详情

温度

100 °C

step 1—A mixture of 2-bromo-6-methoxypyridine (5.00 g), tributylvinyltin (9.30 mL), and PdCl2(PPh)3 in dioxane (100 mL) in a sealed tube was heated overnight at 100° C. The reaction was cooled to RT and the volatile organics were removed under reduced pressure. The crude residue was purified by SiO2 chromatography eluting with a EtOAc/hexane gradient (0 to 10% EtOAc) to afford 2.00 g of 2-methoxy-6-vinyl-pyridine (24) as a colorless oil.

1. temperatureThe reaction was cooled to RT
2. customthe volatile organics were removed under reduced pressure
3. customThe crude residue was purified by SiO2 chromatography
4. washeluting with a EtOAc/hexane gradient (0 to 10% EtOAc)