Hydrogen Bromide → HCID 44624415, compound

Participants

Reaction Steps

step 3—A solution of 36 (69 mg, 0.177 mmol), 48% HBr (0.075 mL, 0.654 mmol) and AcOH (3 mL) in a sealed tube was heated overnight at 60° C. The reaction mixture was cooled to RT, carefully poured into a cold saturated aqueous NaHCO3 solution and then extracted with EtOAc. The organic layer was washed with brine, dried (Na2SO4), filtered and concentrated. The crude residue was purified on a preparative SiO2 TLC plate developed with EtOAc/hexanes to afford 44 mg (66% yield) of 3-[3-(3-amino-benzoyl)-5-tert-butyl-4-methoxy-phenyl]-1H-pyridin-2-one (38 [I-59]) as a light yellow solid.

Provenance & Evidence