HCID 67069993, compound → HCID 67070148, compound

Participants

Reaction Steps

I-66 is prepared by catalytic hydrogenation of 41 with Raney Nickel (MeOH/NH40H) to afford 3-[3-(3-aminomethyl-benzoyl)-5-tert-butyl-4-methoxy-phenyl]-1H-pyridin-2-one. Conversion of the amine to a sulfonamide and cleavage of the pyridinyl ether are carried out in accord with the procedures in step 3 and 4 of example 6.

Provenance & Evidence