反应详情

step 2—To a solution of 40 (124 mg, 0.301 mmol) in DCM (10 mL) at RT was added MnO2 (528 mg, 6.073 mmol). The reaction mixture was vigorously stirred at RT overnight then the solid was filtered through a pad of CELITE. The filtrate was concentrated and the crude residue was purified by SiO2 chromatography eluting with an EtOAc/hexane gradient (5 to 10% EtOAc) to afford 106 mg (86%) of [3-tert-butyl-2-methoxy-5-(2-methoxy-pyridin-3-yl)-phenyl]-(2-chloro-pyridin-4-yl)-methanone (42) as a colorless oil.

1. filtrationthe solid was filtered through a pad of CELITE
2. concentrationThe filtrate was concentrated
3. customthe crude residue was purified by SiO2 chromatography
4. washeluting with an EtOAc/hexane gradient (5 to 10% EtOAc)