HCID 67069886, compound → HCID 67070050, compound

Participants

Reaction Steps

step 4—A mixture of 52 (311 mg, 0.630 mmol) and Pd(OH)2 (20% wt. on carbon, 103 mg, 0.146 mmol) in EtOAc (10 mL) and MeOH (10 mL) was stirred under a H2 atmosphere overnight. The catalyst was filtered, and the filtrate was concentrated. The crude residue was purified by SiO2 chromatography eluting with an EtOAc/hexane gradient (10 to 25% EtOAc) to afford 156 mg (66%) of 2-[2-(4-amino-phenyl)-ethyl]-4-tert-butyl-6-(2-methoxy-pyridin-3-yl)-phenol (54) as a colorless oil.

Provenance & Evidence