HCID 67286765, compound → HCID 67070247, compound

Participants

Reaction Steps

step 5—A mixture of 68 (180 mg, 0.354 mmol) and Pd(OH)2 (20 wt % on C, 75 mg, 0.107 mmol) in EtOAc (10 mL) and MeOH (10 mL) was stirred under an atmosphere of hydrogen for 2 h before the catalyst was filtered, and the filtrate was concentrated. The crude residue was purified by SiO2 chromatography eluting with an EtOAc/hexane gradient (75 to 100% EtOAc) to afford 68 mg (49%) of 3-{3-[2-(4-amino-phenyl)-ethyl]-5-tert-butyl-4-methoxy-phenyl}-6-methyl-1H-pyridin-2-one (70) as a foam.

Provenance & Evidence