Pyridine → HCID 67069936, compound

Participants

Reaction Steps

step 6—To solution of 88 (0.087 g, 0.19 mmol) in DCM (5 mL) at 0° C. was added pyridine (23 □L) and followed by acetic anhydride (0.02 mL, 0.23 mmol). The reaction was allowed to warm to RT and stirred overnight then diluted with DCM and saturated aqueous NaHCO3. The aqueous layer was separated and extracted with DCM. The combined extract was washed with brine, dried (Na2SO4), filtered and concentrated. The crude product was purified on a preparative SiO2 TLC plate developed with 40% EtOAc/hexanes to afford 0.045 g (46%) of N-[4-tert-butyl-2-[2-(4-methanesulfonylamino-phenyl)-ethyl]-6-(2-methoxy-pyridin-3-yl)-phenyl]-acetamide (90) as an off-white solid.

Provenance & Evidence