4-Nitrophenol → HCID 67069940, compound

Participants

Reaction Conditions

Reaction Steps

step 2—A mixture of 114 (0.20 g, 0.59 mmol), 4-nitrophenol (0.082 g, 0.59 mmol) and K2CO3 (0.12 g, 0.89 mmol) in DMF was stirred at 50° C. for 2 h. The mixture was cooled to RT and partitioned between water and Et2O. The ether layer was concentrated, and the crude residue was purified by SiO2 chromatography eluting with EtOAc/hexane to afford 0.19 g (83%) of 5-bromo-1-tert-butyl-2-methoxy-3-(4-nitro-phenoxymethyl)benzene (116) as a white solid.

Provenance & Evidence