HCID 59156764, compound → HCID 44624772, compound

Participants

Reaction Steps

To a suspension of 136 (0.14 g, 0.35 mmol) in MeOH-EtOAc (2:1, 7.5 mL) was added 10% Pd/C (0.014 g), and the reaction mixture was stirred under a hydrogen atmosphere maintained by a balloon for 16 h. The reaction mixture was filtered through diatomaceous earth and the pad was rinsed successively with EtOAc, MeOH and DCM. The combined filtrates were concentrated under reduced pressure, and the crude residue was purified by SiO2 chromatography eluting with EtOAc/hexane to afford 0.095 g (76%) of 3-[3-[2-(4-amino-phenyl)-ethyl]-4-methoxy-5-(1-methylcyclopropyl)phenyl]-1H-pyridin-2-one (I-99) as a light yellow powder.

Provenance & Evidence