HCID 67070107, compound → HCID 67070164, compound

Participants

Reaction Steps

step 2—A suspension of 180 (0.322 g, 0.831 mmol) 20% Pd(OH)2/C (0.146 g) and EtOAc/MeOH (1:1, 40 mL) was hydrogenated in a Parr Shaker under 50 psi of hydrogen for 2 h. The resulting suspension was filtered through CELITE and evaporated. The crude product was purified by SiO2 chromatography eluting with a EtOAc/hexane gradient (0 to 90% EtOAc) to afford 0.183 g of 6-{2-[3-tert-butyl-2-methoxy-5-(2-methoxy-pyridin-3-yl)-phenyl]-ethyl}-pyridin-3-ylamine (182) as a yellow foam.

Provenance & Evidence