Pyridine → HCID 67070129, compound

Participants

Reaction Steps

step 3—To a solution of 182 (0.183 g, 0.467 mmol), pyridine (0.076 mL, 0.935 mmol) and DCM (5 mL) was added dropwise methanesulfonyl chloride (0.268 g, 2.337 mmol). The reaction was stirred overnight at RT then evaporated and taken up in EtOAc, washed with water, dried (MgSO4), filtered and evaporated. The crude product was purified by SiO2 chromatography eluting with an EtOAc/hexane gradient to afford 0.099 g of N-(6-{2-[3-tert-butyl-2-methoxy-5-(2-methoxy-pyridin-3-yl)-phenyl]-ethyl}-pyridin-3-yl)-methanesulfonamide (184) along with the bis-mesylated byproduct.

Provenance & Evidence