Water → HCID 59156758, compound

Participants

Reaction Steps

step b—A solution of 199a, TFA (3 mL), H2O (1 mL) and DCM (10 mL) was heated at reflux for 3 h, cooled and diluted with a ice-water mixture. The pH of the solution was adjusted to ca. 3 with sat'd. NaHCO3 and extracted with EtOAc. The combined extracts were washed with brine, dried, filtered and evaporated to afford N-{3-[3-(2-benzyloxy-pyridin-3-yl)-5-tert-butyl-phenyl]-1-oxo-isochroman-7-yl}-methanesulfonamide (199b)

Provenance & Evidence