Sodium Carbonate → HCID 67070110, compound

Participants

Reaction Steps

step 5—A sealed tube containing 288 (69 mg, 0.144 mmol), 112 (30 mg, 0.216 mmol), Pd(PPh3)4 (16 mg, 0.014 mmol), Na2CO3 (41 mg, 0.387 mmol) in a mixture of MeOH (3 mL) and DCM (1 mL) was irradiated in a microwave reactor at 115° C. for 30 minutes. The reaction mixture was concentrated, diluted with EtOAc, washed with brine, and dried na2so4, filtered and concentrated. The crude product was purified on a SiO2 preparative TLC plate developed with 20% EtOAc/hexane to afford 33 mg (49%) of I-196 a white solid (49% yield).

Provenance & Evidence