Sodium borohydride → HCID 67070283, compound

Participants

Reaction Steps

step 2—To a solution of 292 (117 mg, 0.243 mmol) in MeOH (5 mL) at 0° C. was added sodium borohydride (44 mg, 1.163 mmol). The solution was gradually warmed to RT over 3 h. The reaction was quenched with NH4Cl solution and extracted with EtOAc. The combined extracts were dried (Na2SO4), filtered and concentrated in vacuo to afford 111 mg of N-{4-[2-(5-bromo-3-tert-butyl-2-methoxy-phenyl)-1-hydroxymethyl-1-methyl-ethyl]-phenyl}-methanesulfonamide (294) a white foam (94%).

Provenance & Evidence