Sodium Methoxide → HCID 67070097, compound

Participants

Reaction Steps

step 3—To a solution of 320 (70 mg, 0.125 mmol) in MeOH (10 mL) was added sodium methoxide (10 mL, 5 mmol, 0.5 M MeOH solution). The reaction was stirred at RT overnight. The reaction mixture was concentrated, diluted with EtOAc and acidified with 6N HCl (1 mL). The organic extract was dried (Na2SO4), filtered and concentrated. The crude product was purified on a preparative SiO2 TLC plate developed with 2:1 EtOAc/hexane to afford 28 mg of I-208 as an off-white solid.

Provenance & Evidence