反应详情

step c—A solution of 357b (0.47 g) and acetic anhydride (4.0 mL) was heated at 120° C. for 2 h, The reaction mixture was concentrated in vacuo and purified on a SiO2 column eluting with 5% EtOAc/hexane to afford methyl 5-bromo-6-methoxy-pyridin-2-yl-acetate (357c).

1. concentrationThe reaction mixture was concentrated in vacuo
2. custompurified on a SiO2 column
3. washeluting with 5% EtOAc/hexane