Benzene, 1-bromo-2-(trifluoromethyl)- → HCID 67069935, compound

HRID 2390868Notes

Reaction equation

HRID 2390868 reaction equation
[C:1]([C:5]1[CH:6]=[C:7]([C:25]2[C:26](=[O:31])[NH:27][CH:28]=[CH:29][CH:30]=2)[CH:8]=[C:9](/[CH:13]=[CH:14]/[C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=2C(F)(F)F)[C:10]=1[O:11][CH3:12])([CH3:4])([CH3:3])[CH3:2].[F:32]C1C=CC=CC=1Br.FC(F)(F)C1C=CC=CC=1Br>>[C:1]([C:5]1[CH:6]=[C:7]([C:25]2[C:26](=[O:31])[NH:27][CH:28]=[CH:29][CH:30]=2)[CH:8]=[C:9](/[CH:13]=[CH:14]/[C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=2[F:32])[C:10]=1[O:11][CH3:12])([CH3:2])([CH3:4])[CH3:3]

Participants

4

Reactant 3

HCID 9806Benzene, 1-bromo-2-(trifluoromethyl)-HCID 612591-Bromo-2-fluorobenzeneHCID 67287451HCID 67287451, compound

Product 1

HCID 67069935HCID 67069935, compound

Procedure

3-{3-tert-Butyl-4-methoxy-5-[(E)-2-(2-trifluoromethyl-phenyl)-vinyl]-phenyl}-1H-pyridin-2-one (I-239)) was prepared analogously except in step 2, o-fluoro-bromobenzene was replaced with o-trifluoromethyl-bromobenzene: MS (CI) mz/=429 (M+H).

Sources & evidence

ORD record
ord-f9a7abb79d5e4dadbf64abe8c2603a6d
Source dataset
uspto-grants-2012_09
Patent number
US08273773B2

Reaction notes

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