HCID 67070043, compound → HCID 67070143, compound

Participants

Reaction Steps

step 3—To a solution of 314 (0.029 g, 0.1 mmol) in MeOH (5.0 mL) and EtOAc (4.0 mL) was added Pd(OH)2 (0.005 g). The solution was stirred under 1 atm of H2. After 18 h the mixture was filtered through a pad of CELITE and the filtrate concentrated in vacuo. The crude product was purified by SiO2 chromatography eluting with a MeOH/DCM gradient (1% to 10% MeOH) to 0.018 g (74%) of I-248 as an oil: MS (CI) mz/=476 (M+H).

Provenance & Evidence